Stat to know: The Cowboys' defense allows a third-down conversion just 26% of the time, second-best in the league -- and the Jets' offense converts only 21% of its third downs, the worst in NFL this season. Weinfuss' pick: Cardinals 20, Falcons 17 The 49ers boast the top rushing offense in the NFL, averaging 200 yards per game. Laine's pick: Buccaneers 28, Panthers 24 ET | Fox Matchup rating: 80.7 | Spread: LAR -3.5 (50.5), What to watch for: The ground game will be crucial. One huge stat, Mahomes says ankle injury won't limit his mobility vs. Texans. Look for quarterback Josh Allen and Buffalo offensive coordinator Brian Daboll to push that number to three come Monday. What to know for fantasy: Mahomes has 235 passing yards, 20 rushing yards and multiple passing scores in four straight games. DAL 6-10 10. -- Jenna Laine, Bold prediction: McCaffrey will top 175 all-purpose yards for the fifth time in six games. Quarterback Nick Foles attempted 42 passes in Week 5, but Kmet finished the game with zero targets and played just 21 of 63 offensive snaps. -- Turron Davenport, • Game picks from our NFL experts » Stat to know: Eagles quarterback Carson Wentz has a 53.1 Total QBR this season (25th in the NFL) and a league-leading nine interceptions. Trotter's pick: Seahawks 28, Browns 17 He's a dynamic player and he's definitely the centerpiece of that offense." That could spell trouble for a Rams defense that ranks 15th at stopping the run (107 yards per game). (1:54). "He has a unique skill set. Stat to know: The 0.0 FPI matchup quality -- on a 0-100 scale -- is the worst of any game measured since it was first tracked in 2008. Read more. Stat to know: Minshew needs 235 passing yards to have the most ever by a Jaguars QB through six games. Matchup rating: 64.1 | Spread: GB -4.5 (47), What to watch for: Aaron Rodgers hasn't had one of those Aaron Rodgers games yet this season, the kind when he just shreds a defense. Against this line, Washington's pass rush will get healthy. FINAL ESPN . Matt Bowen has predicted the correct winner of NFL games 68% of the time. But Andy Dalton is second-worst in that category (0.9 QBR). Matchup rating: 61.2 | Spread: PIT -3 (51), What to watch for: After adequately controlling the run game in their first three games, the Steelers saw Miles Sanders and the Eagles exploit some of the weaknesses opened up by their aggressive blitzing. Davenport and Jordan have combined for six sacks and two forced fumbles. Miami is the NFL's worst run defense at 176 yards per game. WSH-MIA | SF-LAR | ATL-ARI The Titans have surrendered eight touchdowns in the passing game this season, and four of those have been to opposing tight ends. He is also 13-5-2 ATS when facing teams that enter with losing records. Do the Falcons uncover a new identity or form of motivation to rattle off a series of wins under interim coach Raheem Morris? Barshop's pick: Chiefs 38, Texans 31 Stat to know: Wentz has gone four consecutive games with a completion percentage south of 60%, the longest active streak in the NFL and the longest by an Eagles starting quarterback since Mike McMahon went seven straight starts in 2005. But he has been under 19 fantasy points in three of his past four games. Yet the only 49ers player with multiple rushing touchdowns this season is Jeff Wilson Jr. (four), who averages 2.9 yards per rush. Humphrey making big name for himself, Bengals leaning on strong connections while trying to snap winless start, From picks to deep passes: Jackson's learning curve still steep, Redskins, Dolphins battle it out in Week 6 Winless Bowl, Dolphins' ideal 2020 draft: Tua Tagovailoa leads bounty of first-rounders, Redskins not changing stance on Haskins after Gruden's firing, Rams off to uneven start, but don't plan on relinquishing NFC West, Behind dynamic run game, 49ers forging a fast and physical identity, Gurley (thigh) doesn't practice; day-to-day, At last, Rodgers vs. Brady in the playoffs, Quinn stays on the defensive with playcalling duties, No more Little Debbies: Chandler Jones remakes his body -- again, Cut 21 combined times, Broncos' Bausby, Rodgers still 'believe'. Mistakes overshadow career days for Cooper, Prescott ... Darnold's return intensifies spotlight on Gase, 8:20 p.m. What to know for fantasy: Miami quarterback Ryan Fitzpatrick has scored at least 21 fantasy points in four straight games, the longest streak of his career. -- Jeff Legwold. If San Francisco can't get it figured out in a hurry, it could be another long night. Matchup rating: 44.6 | Spread: LAC -7 (41.5), What to watch for: The Chargers are allowing 120 rushing yards per game this season, No. -- Nick Wagoner, Bold prediction: Donald will turn in his third multi-sack performance of the season. NFL Week 6 odds, picks: Patriots beat up on Giants, Chiefs rebound against Texans, plus other best bets Other best bets include the Lions hanging tough vs. the Packers See Week 6 rankings. 2 Ben Axelrod's Week 6 NFL picks: Panthers beat Bears, Cowboys upset Cardinals WKYC's Ben Axelrod makes his picks against the spread for every game in Week 6 of the 2020 NFL season. -- Jake Trotter, Bold prediction: Chris Carson and Rashaad Penny will combine for at least 150 yards on the ground, which is about what Cleveland's 29th-ranked rush defense is allowing per game. -- Rob Demovsky, Bold prediction: Kerryon Johnson gains more than 100 yards and scores two touchdowns -- one rushing and one receiving -- to lead the Lions to their third consecutive victory at Lambeau Field. Lock of the week record: 6-1 straight-up, 5-2 against the spread. Betting nugget: The underdog has won all five Tennessee games this season outright. NO-JAX | SEA-CLE | CIN-BAL • Bucs carry hopes of '02 team into Sunday ET | NFL Network The Rams are tied for the NFL lead with 20 sacks, and the Niners have allowed 18, fourth most in the league. What to know for fantasy: The Rams' Cooper Kupp is seeking to become the first player in NFL history with four consecutive games of at least nine catches and a receiving score. -- Mike DiRocco, Bold prediction: Lions quarterback Matthew Stafford will look like the quarterback he was last season, throwing for 330 yards and three touchdowns, in a game that will still come down to the final possession due to Detroit's poor defense against Gardner Minshew -- who will also throw for 300 yards and two scores. DET-GB, Thursday: NE 35, NYG 14 Matchup rating: 50.3 | Spread: TEN -3.5 (53.5), What to watch for: The Titans will be creative in finding ways to pressure Texans quarterback Deshaun Watson. See Week 6 rankings. The Saints' front seven is playing great, and will make Fournette work for it. In Week 5, he racked up 129 yards on eight catches against a divisional foe in the Cowboys. Keim's pick: Washington 21, Giants 20 Read more. Brett Favre gives high praise to Aaron Rodgers so far this season, saying that Rodgers is playing his best football ever. The NFL consensus is a great tool to use when making your NFL picks because you can see what other football bettors are wagering on. FPI prediction: LAR, 53.0% (by an average of 1.1 points), Matchup must-reads: Rams' Sean McVay remains a football junkie even as he attempts to step back ... How Kyle Shanahan has kept the 49ers from falling apart ... Rams have a sack party in Washington as they prepare for NFC West ... 49ers CB Sherman suffers setback in recovery from calf injury ... 49ers QB Garoppolo practices, on track to start, Monday, 5 p.m. On the flip side, the Rams average 96 yards, and the 49ers' front has been among the best in allowing only 82 per game. Betting nugget: Tennessee is 3-11 ATS in games that follow fewer than six days' rest since the start of the 2013 season. But it won't be enough, as Vikings running back Alexander Mattison does his best Dalvin Cook impersonation with more than 100 rushing yards and two scores of his own. What to know for fantasy: Bengals running back Joe Mixon is on pace for 384 touches this season, a number that only Ezekiel Elliott, Le'Veon Bell, Christian McCaffrey and Derrick Henry have hit since 2015. 1 receiver: Vikings' Thielen relishing new roles, McCaffrey doesn't have to rush back for Panthers, Panthers' Short to have season-ending shoulder surgery, How COVID-19 put everything on the line for Panthers' Reed, "A student of everything": What a 26-year-old Bill Belichick learned as a Broncos assistant, Broncos coach Fangio forced to take more risks on defense, Inability to keep Burrow upright is problem Bengals must fix quickly, Colts sticking with Rivers at QB despite turnover trouble, Bengals lose Reader for season with quad injury, Rivers' turnovers responsible for nine points in Colts' loss, Jaguars to use fifth kicker of season in Brown, Jaguars among NFL teams using silver to fight COVID-19, Resetting Washington's QB situation: What's next for Allen, Smith and Haskins, Giants' Jones continues to be haunted by last-minute failures, Smith favored to win comeback player award, Giants lose LB Carter for season with ruptured Achilles, How Bell ouster affects Jets' locker room and future cap, Dolphins' Howard, Jones show potential to be top CB duo, Jets to again start Flacco at QB; Gase to still call plays, Source: Dolphins' Godchaux has biceps tear, Bell's ugly ending with Jets raises serious questions, One night in Atlanta 10 years ago, Rodgers became a star, Brady pokes fun at himself while congratulating LeBron, Brady's fourth-down gaffe joins list of other interesting errors with time and turnovers, Rams' Sean McVay remains a football junkie even as he attempts to step back, How Kyle Shanahan has kept the 49ers from falling apart, Rams have a sack party in Washington as they prepare for NFC West, 49ers CB Sherman suffers setback in recovery from calf injury, 49ers QB Garoppolo practices, on track to start, At last, Rodgers vs. Brady in the playoffs, Missing starters evident in Bills' humbling loss on national stage, Source: Hamstring injury could sideline Chiefs WR Watkins a couple of games, Biggest surprises for every AFC team thus far in the 2020 season, Cardinals LB Jones to have season-ending surgery, Even without Prescott, Cowboys say plan stays the same on offense, Hopkins credits Murray, Cardinals' playcalling for hot start, Could Dak still get $100 million? The matchup in pass protection is heavily tilted toward the Colts. ET | Fox NFL experts debate their title window, future at QB, 2021 NFL draft order: Top 28 picks set, with Jags, Jets, Dolphins at the top, NFL experts predict: Week 6 upset picks, fantasy sleepers, disappointing players, more, Week 6 Love/Hate: Reinvent your fantasy football season with a new format, Projected 2021 NFL draft order: Jaguars clinch No. That's the best win percentage (minimum 10 starts) and most team points per game for a Titans/Oilers QB since the 1970 merger. -- Jenna Laine, • McShay's most recent mock draft » Bold prediction: JuJu Smith-Schuster will have his first 100-yard receiving game this season. 4 overall selection. ET | ESPN But both sides have injuries and questions marks dotting their offensive depth charts. Stat to know: Rams quarterback Jared Goff has a 70% completion rate in three consecutive road games, the second-longest streak in Rams history (Kurt Warner, five). Cleveland (plus 17) at Jacksonville: The Jaguars have only one more game left with a winning team. What to know for fantasy: Bucs receiver Chris Godwin has finished three weeks as a top-10 receiver this season, while teammate Mike Evans has finished outside of the top 45 on three occasions. Keim's pick: Redskins 24, Dolphins 16 • At last, Rodgers vs. Brady in the playoffs, Bold prediction: Running back Clyde Edwards-Helaire will again become a prominent part of the Chiefs' offense and will score his first touchdown since Week 1. They have been considered open -- three or more yards of separation at arrival of the throw -- on 55% of their targets, also the highest mark in the NFL. -- Eric D. Williams. Full ranking » | Pick order » | More », Bold prediction: The Packers' defense will finally make a stand. • At last, Rodgers vs. Brady in the playoffs, Bold prediction: Devonta Freeman will have his first 100-yard rushing game of the season and more than 20 carries as the Falcons finally achieve the balance they've been seeking. Hensley's pick: Ravens 33, Bengals 17 Wagoner's pick: Rams 30, 49ers 27 -- Mike Reiss, Bold prediction: The Broncos will force two turnovers. See Week 6 rankings. Read more. This is a bad matchup for the Bengals, who have allowed 250 rushing yards or more in two of the first five games this season. -- Adam Teicher, Everything you need this week: See Week 6 rankings. -- David Newton, Bold prediction: Bears rookie tight end Cole Kmet will catch at least five passes and one touchdown. NFL odds, lines, picks, predictions for Week 6, 2020: Proven model backing Ravens, Colts SportsLine's computer model simulated every Week 6 NFL game 10,000 times with surprising results. The Texans, who are 12th in the league in scoring defense allowing 22 points per game, offer a significant challenge. Over that stretch, Ryan is QB24 in total points, just 0.5 points ahead of a struggling Sam Darnold, who missed Week 5. -- Josh Weinfuss, • Matthew Stafford gave Lions all he had NFL Week 6 picks: All the rest. So will the Steelers lean on James Conner and the running game to help protect rookie quarterback Devlin Hodges? Newton's pick: Panthers 24, Bears 20 Betting nugget: Detroit has won and covered all four meetings between these two teams in the past two seasons, including three times as an underdog. Baby's pick: Colts 23, Bengals 14 FPI prediction: TB, 53.0% (by an average of 1.1 points), Matchup must-reads: One night in Atlanta 10 years ago, Rodgers became a star ... Brady pokes fun at himself while congratulating LeBron ... Brady's fourth-down gaffe joins list of other interesting errors with time and turnovers, 8:20 p.m. Read more. Can the Panthers, who have not allowed a sack in two straight games, keep quarterback Teddy Bridgewater clean against Chicago's Akiem Hicks and Khalil Mack, who have 3.5 sacks each? Read more. Betting nugget: Over the past two seasons, Atlanta is 6-15 ATS, the worst record in the NFL. Read more. Read more. Matchup rating: 85.0 | Spread: GB -1.5 (55), What to watch for: The Bucs are hopeful that Tom Brady can get back some of his weapons, such as wide receiver Chris Godwin and running back Leonard Fournette, along with a healthier Scotty Miller and Mike Evans. Stat to know: Kansas City quarterback Patrick Mahomes began his 2018 MVP season by completing 64% of his passes for 1,513 yards, 14 touchdowns, two interceptions and an 86.1 Total QBR through five games. Hilton and, even after the historic Week 5, Will Fuller. Stat to know: With Ryan Tannehill starting at quarterback, the Titans are 11-3 (.714) and have averaged 30.4 points per game. This week they lose small. NFL Week 6 NFL Picks: Final Vegas Odds and Predictions for Sunday's Slate ... Pittsburgh talked to former Browns HC earlier in the week about its vacant OC job (ESPN) NFL … ET | Fox Matchup rating: 81.8 | Spread: LAR -3.5 (51.5), What to watch for: The 49ers' struggling offensive line gets its toughest test yet with Aaron Donald & Co. coming to town. Jacksonville offensive coordinator Jay Gruden admitted he has abandoned the run way too soon in each of the Jaguars' past two games, so expect him to commit to Robinson pretty heavily against the Lions. The Dolphins and Redskins are the only two teams in the NFL that rank in the bottom five in both offensive and defensive efficiency. FPI prediction: SEA, 53.9% (by an average of 1.4 points), Matchup must-reads: Wilson's torrid start has him playing at an MVP level ... Browns 'have a lot of concerns,' starting with Mayfield, 1 p.m. -- Cameron Wolfe, Bold prediction: The Jets won't convert more than five third downs. Rookie running back Clyde Edwards-Helaire accounted for 161 of the Chiefs' 245 rushing yards as Kansas City came out victorious. In our picks and predictions for Week 6 of the 2020 NFL season, and the Browns-Steelers AFC North rivalry is a tough pick. Read more. 12 to No. In our NFL picks against the spread for Week 6, Seattle wins a close game in Cleveland. Read more. He caught 11 of 13 targets for 65 yards and a touchdown in his two games against the Steelers last season. -- Josh Weinfuss. -- Mike DiRocco, Bold prediction: Jacksonville's Leonard Fournette will snap the Saints' streak of 31 games without allowing a 100-yard rusher, including the playoffs -- the longest active streak in the NFL. The Texans acquired Carlos Hyde via trade with the Chiefs prior to the regular season, and his 310 rushing yards this season ranks 15th among running backs. Denver's defense is 22nd against the run (126.4 yards per game), a prime spot for the Titans and Henry to get back to their smashmouth style of offense. Betting nugget: Carolina is 3-0 both straight up and ATS in its past three games. Look for the Smiths (Preston Smith and Za'Darius Smith) to have success against the statuesque Brady, and Kenny Clark's return will help a run defense that so far has allowed nearly 5 yards per carry. FPI prediction: WSH, 52.7% (by an average of 1 point), Matchup must-reads: Resetting Washington's QB situation: What's next for Allen, Smith and Haskins ... Giants' Jones continues to be haunted by last-minute failures ... Smith favored to win comeback player award ... Giants lose LB Carter for season with ruptured Achilles, 4:05 p.m. You can bet with or against the public. Betting nugget: Watson is 8-1 ATS in his career as a road underdog, with four outright wins. -- Todd Archer. The Chiefs, on the other hand, have allowed two 100-yard receivers through five games this season. Read more. Stat to know: Atlanta wide receiver Calvin Ridley has an NFL-high four 100-yard receiving games this season. Read more. This is the percentage of the general public betting on each side of a matchup or total. Why? ET | CBS If you like offense, you loved last weekend’s NFL playoff games. It's all here to help get you ready for a loaded weekend of NFL football. Teicher's pick: Chiefs 31, Texans 30 That team finished 1-15. -- Jeff Legwold, Bold prediction: Derrick Henry will rush for more than 100 yards and have two touchdowns. By the fourth quarter, it could be a two-touchdown game and the stadium will be overrun by Dallas fans. As of now, the Jets have a league-high 43.6% chance to get the top pick in the 2021 NFL draft, according to FPI. Rookie quarterback Joe Burrow … See Week 6 rankings. See Week 6 rankings. By James Dator Oct 14, 2020, 7:00am EDT The rookie is tied for the NFL lead with seven total fumbles and four lost fumbles -- three of which happened last weekend -- and the majority have come when he's been sacked or scrambling to avoid a sack. • Depth charts for every team » NFL execs, coaches weigh in on QB's future, Why Favre thinks this is the best Rodgers has ever played (1:54), Guide to every Week 6 NFL game: Picks, matchup nuggets, more, Guide to Buccaneers-Packers, Bills-Chiefs: Picks, bold predictions and more, Sources: Lions actively seek to trade Stafford, Source: Chiefs RB Edwards-Helaire likely to play, Sources: Ex-Chargers coach Lynn to be Lions OC, Fins QB coach hire Frye has familiarity with Tua, Williams eyes NFL first: 2 teams in 1 postseason, Texans interview QB McCown, Caldwell for HC job, Finally, Aaron Rodgers vs. Tom Brady: Inside playoff matchup 13 years in making, Why Chiefs' Patrick Mahomes is the premier practitioner of the free play, Matthew Stafford gave Detroit all he had -- on the field and off of it, How Ryan Jensen became the best - and meanest - center in the game, After 13-year playoff drought, Bucs carry hopes of their last NFC championship team, Getting No. See Week 6 rankings. Betting nugget: Green Bay is 4-0 ATS, making it the only undefeated team ATS left this season. The Bears have too much invested in Kmet for him to be a bystander, so look for Foles to target the rookie early and somewhat often on Sunday. Teacher, coach, No. What to know for fantasy: Tampa Bay running back Ronald Jones is the only player in the NFL this season with multiple games of 100 rushing yards and five targets. What to know for fantasy: Wilson leads the league in touchdown pass percentage (7.7%) and is in search of his third straight season finishing as a top-three player in that metric. -- Turron Davenport. Read more. Since 2015, teams coming off Thursday games are 10-3 ATS against teams coming off Monday games. Baby's pick: Ravens 35, Bengals 14 Betting nugget: Washington is the second team 0-5 or worse to be listed as a road favorite in the Super Bowl era, joining another Redskins team in 1998 (-2.5 at Philadelphia, lost 17-12). 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